What is Myrbetriq’s mechanism of action for treating OAB?

Post written by PHS Staff Writer on May 11, 2023
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### Overactive Bladder Medication: A Closer Look

Do you experience a relentless urge to urinate even when your bladder isn’t full? Do frequent bathroom trips interrupt your day-to-day activities?

If you answered yes, you might be dealing with Overactive Bladder (OAB), a condition affecting millions globally. Thankfully, medications like Myrbetriq are available to help control OAB symptoms.

## How Myrbetriq Manages Overactive Bladder According to Clinical Trials

Myrbetriq, or Mirabegron, is an FDA-approved medication designed for adults with Overactive Bladder. This drug is a selective beta-3 adrenergic receptor agonist that works by relaxing the detrusor muscle in the bladder. Consequently, it allows the bladder to hold more urine, reducing the constant urge to urinate.

Clinical trials underscore the efficacy and safety of Myrbetriq in managing OAB symptoms. In one randomized, double-blind, placebo-controlled study with 1,200 participants, Myrbetriq notably outperformed a placebo in decreasing the frequency of urinary incontinence episodes and urination. Additionally, Myrbetriq led to significant improvements in patient-reported outcomes such as quality of life, treatment satisfaction, and the severity of urinary urgency.

Another significant study found that Myrbetriq considerably lowered the frequency of urgency urinary incontinence (UUI) compared to a placebo. In this randomized, double-blind, placebo-controlled trial, 65% of Myrbetriq-treated patients experienced a UUI reduction of at least 75%, as opposed to 27% among placebo-treated participants.

## Benefits of Myrbetriq for Overactive Bladder

One of Myrbetriq’s standout benefits is its proven effectiveness. As clinical research shows, Myrbetriq can substantially decrease the number of urinary incontinence episodes and frequency in OAB patients. In addition, Myrbetriq has been linked to enhanced patient-reported outcomes, including better quality of life and higher treatment satisfaction.

Another major advantage is its convenience. Unlike some OAB medications that require multiple doses daily, Myrbetriq is taken just once a day. This convenience can help patients, especially older adults or those with busy schedules, stick to their medication regimen more easily.

## Side Effects of Myrbetriq

Myrbetriq is generally well-tolerated. In clinical trials, the most common side effects included headaches, nausea, and urinary tract infections. These side effects were often mild and rarely led to discontinuation of the treatment. However, it’s essential to discuss your medical history and potential side effects with your healthcare provider to determine if Myrbetriq is the right medication for you.

## Is Myrbetriq an Over-the-Counter Medication?

No, Myrbetriq is a prescription medication and is not available over the counter.

However, several over-the-counter options exist for treating OAB. These include antimuscarinics like Oxytrol and Detrol, as well as beta-3 agonists like Oxytrol for Women. Yet, speaking with a healthcare provider before initiating any new medication, including OTC options, is crucial to ensure they are safe and effective for your specific condition.

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