Top Antidepressants to Combine with Abilify

Post written by PHS Staff Writer on November 23, 2022
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### Optimal Antidepressant Combinations with Abilify: A Guide

Adults suffering from major depressive disorder often find that antidepressants alone aren’t always sufficient. In such cases, Abilify can be introduced to enhance the effectiveness of traditional antidepressant therapy.

Antidepressants are commonly prescribed to address anxiety and depression. According to the Centers for Disease Control and Prevention (CDC), 13.2% of American adults used antidepressant medications within a 30-day period during a study conducted between 2015 and 2018.

While antidepressants have significantly assisted in managing depression and anxiety, some individuals may require additional support. Adding medications like Abilify to a treatment plan can potentially improve the overall outcome.

Read on to discover the most effective antidepressants to pair with Abilify.

Abilify and Antidepressants

Though Abilify can be used on its own to treat a range of mental health conditions, its efficacy in treating depression is often maximized when combined with other medications, particularly antidepressants.

Research indicates that antidepressants, although primarily used to treat depression, bring about remission in only one-third of patients. The remaining two-thirds frequently need additional treatments for effective symptom management.

Adding Abilify to an already established treatment plan often yields better results compared to using a single antidepressant alone.

Which Antidepressants Are Compatible with Abilify?

Serotonin and norepinephrine reuptake inhibitors (SNRIs) and selective serotonin reuptake inhibitors (SSRIs) are types of antidepressants that can be effectively combined with Abilify to manage depression more efficiently.

Here are some of the best antidepressants to pair with Abilify:

  • fluoxetine (Prozac)
  • sertraline (Zoloft)
  • escitalopram (Lexapro)
  • paroxetine (Paxil)
  • citalopram (Celexa)
  • fluvoxamine (Luvox)
  • vilazodone (Viibryd)
  • duloxetine (Cymbalta)
  • venlafaxine (Effexor)
  • desvenlafaxine (Pristiq)
  • levomilnacipran (Fetzima)

Note: Although the combination of Abilify (Aripiprazole) with specific antidepressants needs more extensive research, some studies suggest that Lexapro paired with Abilify might be especially effective in treating depression.

Are There Medications to Avoid When Taking Abilify?

Abilify can have adverse reactions when combined with certain drugs, potentially leading to serious complications. Medications that may interact negatively with Abilify include:

  • metoclopramide
  • Adderall
  • clarithromycin
  • itraconazole
  • quinidine
  • Prozac
  • Paxil
  • carbamazepine
  • rifampin
  • lorazepam

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