Comparing Humulin and Humalog: Key Differences Explained

Post written by PHS Staff Writer on April 29, 2022
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When comparing Humulin and Humalog, it’s crucial to understand the key differences between them, which span their uses, types, and potential side effects.

Definitions

Humulin is an artificial insulin designed to supplement the deficiency when the pancreas can’t produce enough natural insulin. This hormone is essential for controlling blood sugar levels.

Humulin comes in various forms, including Humulin R and Humulin N, as well as Humulin 70:30 and Humulin 50:50. These versions cater primarily to individuals with type 2 diabetes.

On the other hand, Humalog is a synthetic insulin analog that helps manage blood sugar variations, especially for those with type 2 diabetes. This insulin is typically administered 15 minutes before or after meals.

Usage

Humulin, also known as insulin isophane, starts to work relatively quickly after administration, taking about 30 minutes to enter the bloodstream and begin its action. In contrast, Humalog acts faster, beginning to work within just 15 minutes of injection.

Types of Humulin

The different types of Humulin include:

  • Humulin R: A short-acting insulin that activates within 30 minutes post-injection and can continue working for up to 8 hours.
  • Humulin N: An intermediate-acting insulin that begins its action 2 to 4 hours after injection, with effects lasting up to 18 hours.
  • Humulin 70:30 / Humulin 50:50: These are combinations of short-acting and intermediate-acting insulin.

Types of Humalog

The types of Humalog include:

  • Insulin Lispro: This is a rapid-acting insulin that activates within 15 minutes of injection and remains effective for 2 to 4 hours.
  • Humalog Mix: A combination insulin that includes protamine, which delays the absorption of insulin.

Side Effects of Humulin and Humalog

Since both medications are forms of insulin, they share common side effects:

  • Hypoglycemia (low blood sugar levels)
  • Unexplained weight gain
  • Vision issues
  • Muscle pain
  • Muscle cramps
  • Irregular heartbeat
  • Mood changes
  • Hypokalemia (low potassium levels)
  • Skin rashes (typically at the injection site)
  • Scarring at the injection site

If you are allergic to these medications, it’s essential to avoid them and seek alternatives from your healthcare provider to ensure safer treatment options.

Takeaway

Both Humulin and Humalog are available in injectable forms. If not in vials, they come in pre-filled pens. For vial forms, always use a clean and sanitized syringe to extract the insulin.

Sources:

Learn more about the differences between Humulin and Humalog here.

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