Asacol Versus Pentasa Comparison

Post written by PHS Staff Writer on January 3, 2023
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### Asacol vs Pentasa: What is the Difference Between Pentasa and [Asacol](https://prohealthsupporter.com/prescription-drugs/asacol/)?

Pentasa (mesalamine) and Asacol (mesalamine) are anti-inflammatory medications employed to treat proctitis, proctosigmoiditis, and ulcerative colitis. Both are also prescribed to prevent the recurrence of ulcerative colitis symptoms. But what sets these two drugs apart?

While the differences between Pentasa and Asacol are minimal, both contain mesalamine to alleviate bowel infections and diseases. Keep reading to understand the nuances of these medications.

 

## **What is Asacol?**

[Asacol](https://prohealthsupporter.com/prescription-drugs/asacol/) (mesalamine) is an anti-inflammatory drug used primarily for treating ulcerative colitis and other inflammatory bowel diseases. It is also used to prevent conditions such as proctitis and proctosigmoiditis.

Additionally, Asacol helps alleviate various ulcerative colitis symptoms, including abdominal discomfort, rectal bleeding, and diarrhea. Mesalamine, the active ingredient in Asacol, belongs to the aminosalicylates class of drugs.

 

## **Asacol Side Effects**

Here are some side effects that might occur while taking [Asacol](https://prohealthsupporter.com/prescription-drugs/asacol/):

  • Headache
  • Nausea
  • Cold symptoms (runny nose, sore throat)
  • Abdominal pain
  • Diarrhea
  • Indigestion
  • Gas
  • Flu-like symptoms
  • Fever
  • Cough

Many of these mild side effects may resolve on their own in a few days to weeks. However, if they persist or impair your daily activities, consult your doctor or pharmacist.

 

## **What is Pentasa?**

Pentasa, another mesalamine-based drug, is FDA-approved for treating ulcerative colitis in adults.

Ulcerative colitis is an inflammatory condition that affects the lining of the colon and rectum, causing ulcers. As a chronic disorder, the symptoms of ulcerative colitis can vary over time, with periods of active flare-ups and remissions.

Pentasa is particularly recommended for:

  • Inducing remission in ulcerative colitis
  • Treating mild to moderate ulcerative colitis

 

## **Pentasa Side Effects**

Mild side effects from Pentasa may include:

  • Joint pain
  • Diarrhea
  • Nausea and vomiting
  • Abdominal pain
  • Upset stomach
  • Headache
  • Hair loss

These side effects often subside within a few days to weeks. However, if they persist or worsen, seek advice from your doctor or pharmacist.

Serious side effects of Pentasa can include:

  • Liver issues: Symptoms may include jaundice and upper right abdominal pain.
  • Kidney problems: Symptoms may include swollen legs, ankles, or feet, decreased urination, nausea, confusion, shortness of breath, and fatigue.
  • Mesalamine-induced acute intolerance syndrome: This condition can cause symptoms similar to ulcerative colitis flare-ups, such as stomach cramps, fever, headache, skin rash, and bloody diarrhea.
  • Severe skin rashes
  • Bloody stools
  • Worsened allergic reactions

Always consult your healthcare provider if you experience any serious side effects.

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