Can Abilify Lead to Weight Gain?

Post written by PHS Staff Writer on January 1, 1970
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Abilify, known medically as an atypical antipsychotic, is often prescribed for individuals who have not seen sufficient improvements with other types of antidepressants. Although some users report experiencing weight gain while taking Abilify, the evidence supporting this is not particularly robust. So, is weight gain a legitimate side effect, or is it just a misconception? Read on to delve into the details behind these claims.

Does Abilify Cause Weight Gain?

In short, YES.

Several factors can contribute to weight gain associated with Abilify, and these factors can vary from person to person.

Here are some ways Abilify might affect your weight:

  • Abilify may increase your appetite.
  • It can raise your blood sugar levels.
  • It might slow down your metabolism.
  • Side effects could decrease your activity levels, leading to less exercise and changes in diet.
  • Weight gain might be more noticeable when Abilify is used in combination with other medications.
  • By improving your mood, Abilify might also boost your desire to eat more.

What Is Abilify?

Abilify is an atypical antipsychotic medication developed by Bristol-Myers Squibb. It works by affecting chemicals in the brain, making it effective for treating various depressive disorders.

Since its FDA approval in 1999, Abilify has been used to treat conditions such as major depressive disorder, bipolar I disorder, and general anxiety disorder. It is also used off-label for managing symptoms associated with autism, epilepsy, and binge eating disorder (BED).

How Does Abilify Work?

Abilify influences brain chemicals that are crucial in regulating mood. These chemicals include norepinephrine (noradrenaline), dopamine, serotonin, and gamma-aminobutyric acid (GABA).

As neurotransmitters, these chemicals facilitate communication between neurons. In individuals experiencing depression, the balance of these neurotransmitters can be disrupted. Medications like Abilify work to rebalance these chemical levels in the brain.

How Much Weight Might You Gain on Abilify?

While Abilify can contribute to weight gain, the amount varies depending on factors including dosage, duration of use, other concurrent medications, and your starting weight. On average, weight gains reported by patients range from 2.2 lbs (1 kg) to potentially up to 90 lbs (40 kg).

How Can You Avoid Weight Gain While Taking Abilify?

If you’re experiencing significant weight gain with Abilify, it’s vital to talk to your doctor. Here are some strategies to manage or prevent weight gain:

  • Maintain a balanced diet, control portion sizes, and reduce consumption of sugary and high-fat foods.
  • Regularly monitor your weight to catch any gradual increases.
  • Engage in daily physical activity for at least one to two hours.
  • Discuss the possibility of adjusting your Abilify dosage with your doctor.
  • Consider switching to a different medication upon your doctor’s advice.
  • If you’re taking Abilify along with another antidepressant, you might consider switching to bupropion, which has less impact on serotonin receptors.
  • Explore the option of adding Topamax (topiramate) at a low dose to manage weight gain.

If you have additional questions or need further support, consider reaching out to Pro Health Support for personalized guidance and assistance in managing your medication and overall health.

Make sure to consult your healthcare provider before making any changes to your medication regimen. Your doctor’s expertise is crucial in finding the most suitable treatment plan for your specific needs.

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