Lispro insulin is a rapid-acting insulin treatment designed to manage hyperglycemia commonly associated with Type 1 and Type 2 diabetes. Mimicking the effects of endogenous human insulin, this peptide hormone is essential for glucose metabolism, produced by the beta cells of the pancreas.
The pancreas secretes insulin to facilitate glucose absorption into internal organs and tissues like the liver, fat cells, and skeletal muscle. Additionally, insulin inhibits hepatic glucose production, enhances protein synthesis, and prevents lipolysis and proteolysis.
Understanding the Peak of Insulin Lispro
Insulin Lispro is an analog insulin, created by genetically modifying human insulin. This modification allows it to be absorbed faster and last a shorter duration than traditional insulin.
Here are critical points about Insulin Lispro’s action:
- Onset within 0 to 15 minutes post-administration.
- Peaks between 30 to 90 minutes
- Duration of effect is less than five hours
This means Insulin Lispro can be administered 15 minutes before a meal. It offers a safety advantage over conventional insulin, which requires administration 30 minutes before eating, especially if a meal is missed or delayed, reducing the risk of hypoglycemia.
Production Process of Insulin Lispro
Insulin Lispro is a genetically modified insulin analog, with modifications specifically involving the exchange of amino acids: proline at B-28 is replaced by lysine at B-29.
This alteration causes the insulin to dissolve more rapidly into dimers and monomers, resulting in faster absorption following subcutaneous injection.
Besides reducing blood sugar levels similarly to other insulin types, Insulin Lispro offers additional benefits:
- Quicker subcutaneous absorption
- Higher and earlier peak insulin levels
- Faster post-peak decline
Note: There’s also an Insulin Lispro protamine suspension that acts longer. Humalog 75:25 combines Insulin Lispro protamine suspension (intermediate-acting insulin) with Insulin Lispro (short-acting insulin).
For more detailed guidance and support, you can visit our trusted partner, Pro Health Support.