Antidepressants are FDA-approved medications designed to treat depression, anxiety, and various other mental health conditions. While they are effective in managing these disorders, antidepressants can also bring several side effects, including weight loss.
This article explores how antidepressants influence weight.
Antidepressants Associated with Weight Loss
There are three antidepressants commonly linked to weight loss:
- Bupropion (Aplenzin, Forfivo, Wellbutrin); which has the most substantial evidence supporting its connection to weight loss.
- Fluoxetine (Prozac); though the effects are mixed, some patients report losing weight.
- Duloxetine (Cymbalta); the outcomes are not definitive, but some individuals experience weight loss.
During the initial months of treatment, SSRIs like fluoxetine (Prozac) and SNRIs such as duloxetine (Cymbalta) can reduce appetite, leading to weight loss. Bupropion (Wellbutrin), which works by inhibiting the release of norepinephrine and dopamine, might also have a similar effect on your weight.
The impact of fluoxetine (Prozac) on weight varies, with only a few patients noting weight loss. Moreover, while it may promote weight loss in the short term, it could result in weight gain after six months or more.
Here are additional antidepressants that can contribute to weight loss:
- Amitriptyline (Elavil)
- Imipramine (Tofranil)
- Nortriptyline (Aventyl)
- Paroxetine (Paxil, Pareva)
- Mirtazapine (Remeron)
Although many SSRIs are linked to short-term weight loss, other research indicates these medications could cause long-term weight gain. However, further studies are required to understand and explain these effects comprehensively.
If you experience significant weight loss after starting an antidepressant, consult your doctor to discuss the treatment and its implications for your overall health.
Can Antidepressants Cause Weight Gain?
Yes, weight gain is also a common side effect of nearly all antidepressants. However, it is crucial to understand that individuals respond differently to these medications. Some people may gain weight while others might not experience any change.
Antidepressants are not always the direct cause of weight gain. In fact, weight gain during antidepressant treatment can result from various factors:
- Weight gain may occur due to depression-related overeating or a lack of physical activity.
- Some people who are depressed might lose weight for biological reasons, while weight gain may happen due to increased appetite associated with an improved mood.
- Independent of medication, adults typically tend to gain weight as they age.